Pathology - Ruminants

Ruminants

Keratoconjunctivitis (Pink-eye)

Figure 1. Infectious bovine keratoconjunctivitis in a calf. Note the corneal vascularization, stromal abscess, and scars.
Source: Bruce H.G., Cheryl L.C. and Robert L.P. (2004) Veterinary ophthalmology essentials, 1st edn., Philadelphia: Elsevier.

  • Found in sheep, goats and calves
  • Primary infection occurs by Chlamydiae
  • Chlamydiae: Gram negative, obligatory intra cellular parasites
  • Cytoplasmatic inclusion bodies in corneal cells found in the infected animals
  • Clinical signs
    • Watery discharge from the eye
    • Clouding of the cornea
    • Secondary bacterial infection is common due to mechanical damage of the cornea and altered local defence system allowing potential pathogenic bacteria to contribute to secondary infections
  • Treatment
    • Vaccination
      • Penicillins, spectinomycin or other aminocyclitols do not respond
      • Tetracyclines respond
    • High and steady plasma levels of suitable antibiotics for more than one week

Thelazia rhodesi (Eye Worms)

File:Thelazis01.jpg
Figure 2: Presence of Thelazia. 
Source: University of Sydney Centre for Veterinary Education (2012) Thelazia spp, Available at:http://vetbook.org/wiki/cow/index.php/Thelazia_spp (Accessed: 3rd June 2014).

  • Parasite of domestic animals, wild animals and less commonly horses
  • Occurs at surface of cornea, near nictitating membrane, in conjunctival sac and lachrymal duct
  • Transmission occurs through route of flies that feed on animal's ocular secretions, tears and conjunctiva.
  • Clinical signs
    • Conjunctivitis
    • Keratitis
    • Lacrimation
    • Ocular discharge
    • Ulcers
    • Corneal opacity
    • Epiphora - excessive tears production
  • Treatment
    • Mechanical removal of worms using forceps after putting anesthesia 
    • Topical treatment with antiparasitic drugs applied to eyes directly
    • Irrigate with aqueous solution of Boric powder
    • Concurrent use with Ciplox-D (Ciprofloxacin and dexamethasone) eye drops every 8 hours for 5 days 
      • suppression of inflammation & secondary bacterial infections.
    • Ivermectin to be injected subcutaneously @ 0.2mg/Kg bodyweight
    • Fly control

Reference
  1. Bogaard A.E.J.M. (2011) 'Veterinary Quarterly', Inclusion keratoconjunctivitis ('pink eye') in sheep, 6(4), pp. 229 -235.
  2. Bruce H.G., Cheryl L.C. and Robert L.P. (2004) Veterinary ophthalmology essentials, 1st edn., Philadelphia: Elsevier.
  3. Deepthi B. and Yalavarthi C. (2012) 'Eye Worm infection in a Cattle - A Case Report', Veterinary World, 5(4), pp. 236-237.
  4. Naem S. (2006) 'Thelazia rhodesi (Spirurida,  Thelaziidae), bovine eyeworm: morphological study by scanning electron microscopy', Parasitol Research, 100, pp. 855-860.
  5. Otranto D., Tarsitano E., Tarversa D., Giangaspero A., DeLuca F. and Puccini V. (2001) 'Differentiation among three species of bovine Thelazia (Nematoda: Thelaziidae) by polymerase chain reaction–restriction fragment length polymorphism of the first internal transcribed spacer ITS-1 (rDNA)', International Journal of Parasitlogy, 31(14), pp. 1693-1698.
  6. Otranto D. and Traversa D. (2005) 'Thelazia eyeworm: an original endo- and ecto- parasitic nematode' Trends in Parasitology, 21(4), pp. 1-4.
  7. University of Sydney Centre for Veterinary Education (2012) Thelazia spp, Available at:http://vetbook.org/wiki/cow/index.php/Thelazia_spp (Accessed: 3rd June 2014).